NOTCH3 Antibody

• Gene Name:

  Notch 3

• Gene Aliases:

  IMF2, LMNS, CASIL, CADASIL, CADASIL1

• Gene ID:

  4854

• Swiss Prot:

  Q9UM47

• Accession Number:

  NP_000426.2

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human NOTCH3

• Target:

  This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, IF

• Purification:

  Affinity purification.

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid.// PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

• Reconstitution:

  Store at -20C. Avoid repeated freeze/thaw cycles.

• Molecular Weight:

  244 kDa

• Fragment:

  IgG

• NCBI Gene Symbol:

  NOTCH3

• Host or Source:

  Rabbit

• Protein Name:

  Neurogenic locus notch homolog protein 3

• Gene Name URL:

  NOTCH3

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_000435.2