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ORC1L Antibody

CAT: 0247-OAAL00227-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAL00227-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Origin recognition complex subunit 1
Gene Aliases
HSORC1; ORC1L; origin recognition complex subunit 1; origin recognition complex, subunit 1 homolog; PARC1; replication control protein 1.
Gene ID
4998
Accession Number
https://www.ncbi.nlm.nih.gov/protein/AAH11539
Reactivity
Human, Mouse
Immunogen
ORC1L (AAH11539, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Target
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. [provided by RefSeq
Clonality
Monoclonal
Clone
3H1
Type
Monoclonal Antibody
Sequence
MAHYPTRLKTRKTYSWVGRPLLDRKLHYQTYREMCVKTEGCSTEIHIQIGQFVLIEGDDDENPYVAKLLELFEDDSDPPPKKRARVQWFVRFCEVPACKRHLLGRKPGAQ
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
Store at -20C or lower. Aliquot to avoid repeated freezing and thawing.
Fragment
IgG2b Kappa
NCBI Gene Symbol
ORC1
Host or Source
Mouse
Protein Name
Homo sapiens origin recognition complex, subunit 1-like (yeast), mRNA (cDNA clone MGC:9175 IMAGE:3870637), complete cds|Origin recognition complex, subunit 1-like (yeast) [Homo sapiens]
Gene Name URL
ORC1
Nucleotide Accession Number
https://www.ncbi.nlm.nih.gov/nuccore/BC011539

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