CEP152 Antibody

• Gene Aliases:

  MCPH4, MCPH9, SCKL5

• Gene ID:

  22995

• Swiss Prot:

  O94986

• Accession Number:

  NP_001181927

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human CEP152

• Target:

  Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles . Overexpression of CEP152 can drive amplification of centrioles.

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Immunogen affinity chromatography

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/mL

• Format:

  Liquid

• Reconstitution:

  Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.

• Molecular Weight:

  140 kDa

• NCBI Gene Symbol:

  CEP152

• Host or Source:

  Rabbit

• Protein Name:

  Centrosomal protein of 152 kDa

• Gene Name URL:

  CEP152

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001194998