GRB2 Antibody

• Gene Aliases:

  ASH, Grb3-3, MST084, NCKAP2, MSTP084, EGFRBP-GRB2

• Gene ID:

  2885

• Swiss Prot:

  P62993

• Accession Number:

  NP_002077

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human GRB2, corresponding to a region within C-terminal amino acids.

• Target:

  Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification:

  Peptide affinity chromatography

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/mL

• Format:

  Liquid// PBS (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol

• Reconstitution:

  Store at -20° C. Stable for 12 months from date of receipt.

• Molecular Weight:

  25 kDa

• Fragment:

  IgG

• NCBI Gene Symbol:

  GRB2

• Host or Source:

  Rabbit

• Protein Name:

  Growth factor receptor-bound protein 2

• Gene Name URL:

  GRB2

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_002086