MLKL Antibody

• Gene Aliases:

  HMLKL

• Gene ID:

  197259

• Swiss Prot:

  Q8NB16

• Accession Number:

  NP_001135969

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human MLKL.

• Target:

  Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, IF, ICC

• Purification:

  The antiserum was purified by peptide affinity chromatography

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/mL

• Format:

  Liquid.// PBS pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Reconstitution:

  Store at -20° C. Stable for 12 months from date of receipt._x005F

• Molecular Weight:

  54 kDa

• Fragment:

  IgG

• Specificity:

  MLKL Ab detects endogenous levels of total MLKL.

• NCBI Gene Symbol:

  MLKL

• Host or Source:

  Rabbit

• Protein Name:

  Mixed lineage kinase domain-like protein

• Gene Name URL:

  MLKL

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001142497