EIF6 Antibody

• Gene Aliases :

  CAB, EIF3A, eIF-6, p27BBP, ITGB4BP, b (2) gcn, p27 (BBP)

• Gene ID :

  3692

• Swiss Prot :

  P56537

• Accession Number :

  NP_001254739

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant proteinof human EIF6

• Target :

  Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1) -dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis . Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC) . Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth .UniRule annotation

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Applications :

  WB, IHC

• Purification :

  Immunogen affinity chromatography

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1 mg/mL

• Format :

  Liquid

• Reconstitution :

  Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.

• Molecular Weight :

  27 kDa

• NCBI Gene Symbol :

  EIF6

• Host or Source :

  Rabbit

• Protein Name :

  Eukaryotic translation initiation factor 6

• Gene Name URL :

  EIF6

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001267810