MTOR Antibody (Phospho-Ser2448)

• Gene Name:

  Mechanistic target of rapamycin (serine/threonine kinase)

• Gene Aliases:

  SKS, FRAP, FRAP1, FRAP2, RAFT1, RAPT1

• Gene ID:

  2475

• Swiss Prot:

  P42345

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human mTOR around the phosphorylation site of Serine 2448

• Target:

  An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification:

  Immunogen affinity purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Liquid. Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Reconstitution:

  Store at -20C. Stable for 12 months from date of receipt.

• Molecular Weight:

  289 kDa

• Specificity:

  Phospho-mTOR (Ser2448) antibody detects endogenous levels of mTOR only when phosphorylated at Serine 2448

• NCBI Gene Symbol:

  MTOR

• Host or Source:

  Rabbit

• Gene Name URL:

  MTOR

• CAS Number:

  9007-83-4