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AIF (1B7) Mouse mAb

CAT: 0247-OAAH00022-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OAAH00022-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Aliases
AIF, AUNX1, CMT2D, CMTX4, COWCK, DFNX5, NADMR, NAMSD, PDCD8, COXPD6, SEMDHL
Gene ID
9131
Swiss Prot
O95831
Reactivity
Human, Rat, Monkey, Chinese hamster, Dog
Immunogen
This Aviva monoclonal antibody is produced by immunizing mice with asynthetic peptide (KLH-coupled) corresponding to residues within the carboxy terminus of AIF.
Target
A key event in the apoptotic process is the opening of the mitochondrial permeability transition pore, an event that is regulated by Bcl-2 family proteins, resulting in the release of several proteins from the mitochondrial intermembrane space. Several of these proteins participate in apoptosis, including cytochrome c, procaspases 2, 3, and 9 and AIF (apoptosis-inducing factor) . AIF was shown to cause DNA fragmentation and chromatin condensation, and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression was shown to prevent the release of AIF from mitochondria, but not to block its apoptogenic activity.
Clonality
Monoclonal
Type
Monoclonal Antibody
Source
Mouse mAb
Applications
WB
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Reconstitution
Store the product at -20C. Stable for one year from the date of shipment.
Molecular Weight
67 kDa
Fragment
Mouse IgG1
Specificity
AIF (1B7) Mouse mAb detects endogenous levels of total AIF protein.
NCBI Gene Symbol
AIFM1
Host or Source
Mouse
Protein Name
Apoptosis-inducing factor 1, mitochondrial
Gene Name URL
AIFM1

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