TP63 Antibody

• Gene Name:

  Tumor protein p63

• Gene Aliases:

  AIS; amplified in squamous cell carcinoma; B (p51A) ; B (p51B) ; chronic ulcerative stomatitis protein; EEC3; keratinocyte transcription factor KET; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L; transformation-related protein 63; tumor protein 63; tumor protein p53-competing protein; Tumor protein p73-like.

• Gene ID:

  8626

• Swiss Prot:

  Q9H3D4

• Accession Number:

  NP_001108450.1

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide.

• Target:

  Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

• Clonality:

  Monoclonal

• Clone:

  ABT-P63

• Type:

  Monoclonal Antibody

• Applications:

  Immunohistochemistry, Western blot

• Purification:

  Immunogen affinity purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  PBS, pH7.2, 0.03% Proclin 300, 50% glycerol

• Reconstitution:

  -20°C

• Molecular Weight:

  77 kDa

• Fragment:

  IgG

• Specificity:

  Anti-p63 [ABT-P63] detects endogenous levels of total p63 protein.

• NCBI Gene Symbol:

  TP63

• Host or Source:

  Mouse

• Protein Name:

  Tumor protein 63

• Gene Name URL:

  TP63

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001114978.1