KRT17 Antibody

• Gene Name:

  Keratin 17

• Gene Aliases:

  39.1; CK-17; cytokeratin-17; K17; keratin 17, type I; keratin, type I cytoskeletal 17; Keratin-17; PC; PC2; PCHC1.

• Gene ID:

  3872

• Swiss Prot:

  Q04695

• Accession Number:

  NP_000413.1

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide

• Target:

  Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity) . Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity) . Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity) . Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity) . May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

• Clonality:

  Monoclonal

• Clone:

  ABT-CK17

• Type:

  Monoclonal Antibody

• Applications:

  Immunohistochemistry, Western blot

• Purification:

  Immunogen affinity purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  PBS, pH7.2, 0.03% Proclin 300, 50% glycerol

• Reconstitution:

  -20°C

• Molecular Weight:

  48 kDa

• Fragment:

  IgG

• Specificity:

  Anti-Cytokeratin 17 [ABT-CK17] detects endogenous levels of total Cytokeratin 17 protein.

• NCBI Gene Symbol:

  KRT17

• Host or Source:

  Mouse

• Protein Name:

  Keratin, type I cytoskeletal 17

• Gene Name URL:

  KRT17

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_000422.2