PTPRC Antibody

• Gene Name :

  Protein tyrosine phosphatase receptor type C

• Gene Aliases :

  B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; Leukocyte common antigen; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen.

• Gene ID :

  5788

• Swiss Prot :

  P08575

• Accession Number :

  NP_002829.3

• Reactivity :

  Human

• Immunogen :

  Synthetic peptide.

• Target :

  Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) .

• Clonality :

  Monoclonal

• Clone :

  ABT-CD45

• Type :

  Monoclonal Antibody

• Applications :

  Immunohistochemistry

• Purification :

  Immunogen affinity purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format :

  PBS, pH7.2, 0.03% Proclin 300, 50% glycerol

• Reconstitution :

  -20°C

• Molecular Weight :

  131 kDa

• Fragment :

  IgG

• Specificity :

  Anti-CD45 (LCA) [ABT-CD45] detects endogenous levels of total CD45 (LCA) protein.

• NCBI Gene Symbol :

  PTPRC

• Host or Source :

  Mouse

• Protein Name :

  Receptor-type tyrosine-protein phosphatase C

• Gene Name URL :

  PTPRC

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_002838.4