CD163 Antibody

• Gene Name:

  CD163 molecule

• Gene Aliases:

  Hemoglobin scavenger receptor; M130; macrophage-associated antigen; MM130; SCARI1; scavenger receptor cysteine-rich type 1 protein M130.

• Gene ID:

  9332

• Swiss Prot:

  Q86VB7

• Accession Number:

  NP_004235.4

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide

• Target:

  Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

• Clonality:

  Monoclonal

• Clone:

  ABT-CD163

• Type:

  Monoclonal Antibody

• Applications:

  Immunohistochemistry

• Purification:

  Immunogen affinity purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  PBS, pH7.2, 0.03% Proclin 300, 50% glycerol

• Reconstitution:

  -20°C

• Molecular Weight:

  125 kDa

• Fragment:

  IgG

• Specificity:

  Anti-CD163 [ABT-CD163] detects endogenous levels of total CD163 protein.

• NCBI Gene Symbol:

  CD163

• Host or Source:

  Mouse

• Protein Name:

  Scavenger receptor cysteine-rich type 1 protein M130

• Gene Name URL:

  CD163

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_004244.5