ENG Antibody

• Gene Name:

  Endoglin

• Gene Aliases:

  CD105 antigen; END; endoglin; HHT1; ORW1.

• Gene ID:

  2022

• Swiss Prot:

  P17813

• Accession Number:

  NP_000109.1

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide.

• Target:

  Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529) . Required for normal structure and integrity of adult vasculature (PubMed:7894484) . Regulates the migration of vascular endothelial cells (PubMed:17540773) . Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity) . May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity) . May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830) . Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529) . Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529) .

• Clonality:

  Monoclonal

• Clone:

  ABT-CD105

• Type:

  Monoclonal Antibody

• Applications:

  Immunohistochemistry

• Purification:

  Immunogen affinity purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  PBS, pH7.2, 0.03% Proclin 300, 50% glycerol

• Reconstitution:

  -20°C

• Molecular Weight:

  70 kDa

• Fragment:

  IgG

• Specificity:

  Anti-CD105 (Endoglin) [ABT-CD105] detects endogenous levels of total CD105 (Endoglin) protein.

• NCBI Gene Symbol:

  ENG

• Host or Source:

  Mouse

• Protein Name:

  Endoglin

• Gene Name URL:

  ENG

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_000118.3