Bazedoxifene

• Description :

  Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

• Product Name Alternative :

  TSE-424

• UNSPSC :

  12352005

• Hazard Statement :

  H360

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bazedoxifene.html

• Concentration :

  10mM

• Purity :

  99.35

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51

• Molecular Formula :

  C30H34N2O3

• Molecular Weight :

  470.60

• Precautions :

  H360

• References & Citations :

  [1]Barry S Komm, et al. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology. 2005 Sep;146 (9) :3999-4008.|[2]Xiaojuan Wu, et al. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Mol Cancer Ther. 2016 Nov; 15 (11) : 2609–2619.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Citation 01 :

  Arch Biochem Biophys. 2025 Jun:768:110366.|biorxiv. 2024 May 21.|Breast Cancer Res Treat. 2020 Jan;179 (1) :67-77.|Eur J Pharmacol. 2023 May 15:947:175681.|Free Radic Biol Med. 2023 Aug 20:205:163-174.|Glia. 2023 Feb;71 (2) :284-304.|Gynecol Oncol. 2019 Jul;154 (1) :199-206.|J Cell Biochem. 2023 Sep;124 (9) :1404-1422.|Res Sq. 2020 Dec 31:rs.3.rs-100914.|Research Square Preprint. 2022 Jul.|University of Colorado Denver. 2024.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|J Med Chem. 2020 Oct 8;63 (19) :11085-11099.|mSphere. 2020 Apr 8;5 (2) :e00124-20.

• CAS Number :

  [198481-32-2]