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MaxiK Alpha Antibody

CAT: 0247-OAAF05841-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF05841-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Potassium calcium-activated channel subfamily M alpha 1
Gene Aliases
BA205K10.1; big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCA alpha; BKCA alpha subunit; BKTM; CADEDS; Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; hSlo; IEG16; k (VCA) alpha; KCa1.1; LIWAS; Maxi K channel; MaxiK; maxi-K channel HSLO; mSLO1; PNKD3; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; SAKCA; SLO; slo homolog; SLO1; SLO-ALPHA; slowpoke homolog; stretch-activated Kca channel.
Gene ID
3778
Swiss Prot
Q12791
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human MaxiKalpha.
Target
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca (2+) that mediates export of K (+) . It is also activated by the concentration of cytosolic Mg (2+) . Its activation dampens the excitatory events that elevate the cytosolic Ca (2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca (2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Reconstitution
-20°C
Molecular Weight
137 kDa
Specificity
MaxiKalpha antibody detects endogenous levels of MaxiKalpha.
NCBI Gene Symbol
KCNMA1
Host or Source
Rabbit
Protein Name
Calcium-activated potassium channel subunit alpha-1
Gene Name URL
KCNMA1

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