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SLC24A6 Antibody

CAT: 0247-OAAF04318-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF04318-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Solute carrier family 8 member B1
Gene Aliases
Mitochondrial sodium/calcium exchanger protein; Na (+) /K (+) /Ca (2+) -exchange protein 6; NCKX6; NCLX; SLC24A6; sodium/calcium exchanger protein, mitochondrial; Sodium/potassium/calcium exchanger 6; sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 (sodium/lithium/calcium exchanger), member 6; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6; solute carrier family 24 member 6; solute carrier family 8 (sodium/lithium/calcium exchanger), member B1; Solute carrier family 8 member B1.
Gene ID
80024
Swiss Prot
Q6J4K2
Accession Number
NP_079235.2
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human SLC24A6.
Target
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928) . Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity) . Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385) . Required for store-operated Ca (2+) entry (SOCE) and Ca (2+) release-activated Ca (2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928) . Involved in B-lymphocyte chemotaxis (By similarity) . Able to transport Ca (2+) in exchange of either Li (+) or Na (+), explaining how Li (+) catalyzes Ca (2+) exchange (PubMed:15060069) . In contrast to other members of the family its function is independent of K (+) (PubMed:15060069) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid.// PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Reconstitution
-20°C
Molecular Weight
64 kDa
Notes
Formerly GWB-ASF028
Fragment
IgG
Specificity
SLC24A6 antibody detects endogenous levels of total SLC24A6 protein.
NCBI Gene Symbol
SLC8B1
Host or Source
Rabbit
Protein Name
Mitochondrial sodium/calcium exchanger protein
Gene Name URL
SLC8B1

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