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ARHGEF5 Antibody

CAT: 0247-OAAF04193-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF04193-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Rho guanine nucleotide exchange factor 5
Gene Aliases
Ephexin3; ephexin-3; GEF5; guanine nucleotide regulatory protein TIM; oncogene TIM; P60; p60 TIM; Rho guanine nucleotide exchange factor (GEF) 5; rho guanine nucleotide exchange factor 5; TIM; TIM1; transforming immortalized mammary oncogene.
Gene ID
7984
Swiss Prot
Q12774
Accession Number
NP_005426.2
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ARHGEF5.
Target
Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624) . Strongly activates RHOA (PubMed:15601624) . Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity) . Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624) . Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653) . Required for SRC-induced podosome formation (By similarity) . Involved in positive regulation of immature dendritic cell migration (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
60 kDa
Notes
Formerly GWB-ASE952
Specificity
ARHGEF5 antibody detects endogenous levels of total ARHGEF5 protein.
NCBI Gene Symbol
ARHGEF5
Host or Source
Rabbit
Protein Name
Rho guanine nucleotide exchange factor 5
Gene Name URL
ARHGEF5

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