PARP3 Antibody

CAT: 0247-OAAF03060-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0247-OAAF03060-100UGSize:100 µg
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CAS Number
9007-83-4
Gene Name
Poly (ADP-ribose) polymerase family member 3
Gene Aliases
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) -like 2; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) -like 3; ADP-ribosyltransferase diphtheria toxin-like 3; ADPRT3; ADPRT-3; ADPRTL2; ADPRTL3; ARTD3; DNA ADP-ribosyltransferase PARP3; IRT1; NAD (+) ADP-ribosyltransferase 3; NAD+ ADP-ribosyltransferase 3; PADPRT-3; poly [ADP-ribose] polymerase 3; poly (ADP-ribose) synthetase-3; poly[ADP-ribose] synthase 3; poly[ADP-ribose] synthetase 3; protein mono-ADP-ribosyltransferase PARP3.
Gene ID
10039
Swiss Prot
Q9Y6F1
Accession Number
NP_001003931.2
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PARP3.
Target
Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
60 kDa
Specificity
PARP3 antibody detects endogenous levels of total PARP3 protein.
NCBI Gene Symbol
PARP3
Host or Source
Rabbit
Protein Name
Poly [ADP-ribose] polymerase 3
Gene Name URL
PARP3

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