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CYP3A4 Antibody

CAT: 0247-OAAF02960-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF02960-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Cytochrome P450 family 3 subfamily A member 4|cytochrome P450 family 3 subfamily A member 5
Gene Aliases
1,4-cineole 2-exo-monooxygenase;1,8-cineole 2-exo-monooxygenase; Albendazole monooxygenase; albendazole monooxygenase (sulfoxide-forming) ; albendazole sulfoxidase; aryl hydrocarbon hydroxylase; cholesterol 25-hydroxylase; CP33; CP34; CP35; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; CYPIIIA5; cytochrome P450 3A3; cytochrome P450 3A4; cytochrome P450 3A5; cytochrome P450 HLp; cytochrome P450 HLp2; cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; cytochrome P450-PCN1; cytochrome P450-PCN3; flavoprotein-linked monooxygenase; glucocorticoid-inducible P450; HLP; microsomal monooxygenase; NF-25; nifedipine oxidase; P450C3; P450-III, steroid inducible; P450PCN1; P450PCN3; PCN3; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; VDDR3; xenobiotic monooxygenase.
Gene ID
1576|1577
Swiss Prot
P08684|P20815
Accession Number
NP_000768.1
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 3A4/5.
Target
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812) . Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid.// PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Reconstitution
-20°C
Molecular Weight
57 kDa
Notes
Formerly GWB-ASE135
Specificity
Cytochrome P450 3A4/5 antibody detects endogenous levels of total Cytochrome P450 3A4/5 protein.
NCBI Gene Symbol
CYP3A4|CYP3A5
Host or Source
Rabbit
Protein Name
Cytochrome P450 3A4|Cytochrome P450 3A5
Gene Name URL
CYP3A4|CYP3A5

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