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HTR2A Antibody

CAT: 0247-OAAF02800-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF02800-100UGSize:100 µg
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Description
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CAS Number
9007-83-4
Gene Name
5-hydroxytryptamine receptor 2A
Gene Aliases
5-HT2 receptor;5-HT2A;5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled;5-hydroxytryptamine receptor 2A; HTR2; serotonin 5-HT-2A receptor; Serotonin receptor 2A.
Gene ID
3356
Swiss Prot
P28223
Accession Number
NP_000612.1
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human 5-HT-2A.
Target
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895) . Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1- (2,5-dimethoxy-4-iodophenyl) -2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538) . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538) . Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538) . Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca (2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538) . Affects neural activity, perception, cognition and mood (PubMed:18297054) . Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
52 kDa
Notes
Formerly GWB-ASD991
Specificity
5-HT-2A antibody detects endogenous levels of total 5-HT-2A protein.
NCBI Gene Symbol
HTR2A
Host or Source
Rabbit
Protein Name
5-hydroxytryptamine receptor 2A
Gene Name URL
HTR2A

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