KAT5 Antibody

• Description:

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• Gene Name:

  Lysine acetyltransferase 5

• Gene Aliases:

  60 kDa Tat-interactive protein; cPLA (2) -interacting protein; cPLA2; cPLA2 interacting protein; ESA1; histone acetyltransferase HTATIP; histone acetyltransferase KAT5; HIV-1 Tat interactive protein, 60kDa; HTATIP; HTATIP1; K (lysine) acetyltransferase 5; K-acetyltransferase 5; Lysine acetyltransferase 5; NEDFASB; PLIP; Tat interacting protein, 60kDa; TIP; TIP60; ZC2HC5.

• Gene ID:

  10524

• Swiss Prot:

  Q92993

• Accession Number:

  NP_001193762.1

• Reactivity:

  Human|Mouse|Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human TIP60.

• Target:

  Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565) . Acetylates RAN at 'Lys-134' (PubMed:29040603) .

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Dilution:

  The optimal working dilution should be determined by the end user.

• Format:

  Liquid

• Reconstitution:

  -20°C

• Molecular Weight:

  58 kDa

• Notes:

  Formerly GWB-ASD812

• Specificity:

  TIP60 antibody detects endogenous levels of total TIP60 protein.

• NCBI Gene Symbol:

  KAT5

• Host or Source:

  Rabbit

• Protein Name:

  Histone acetyltransferase KAT5

• Gene Name URL:

  KAT5

• CAS Number:

  9007-83-4