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KLF11 Antibody

CAT: 0247-OAAF02396-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF02396-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Kruppel like factor 10|Kruppel like factor 11
Gene Aliases
Early growth response-alpha; EGRA; EGR-alpha; FKLF; FKLF1; Krueppel-like factor 10; Krueppel-like factor 11; MODY7; TGFB-inducible early growth response protein 1; TGFB-inducible early growth response protein 2; TIEG; TIEG1; TIEG2; TIEG-2; Tieg3; transforming growth factor-beta-inducible early growth response protein 1; transforming growth factor-beta-inducible early growth response protein 2; zinc finger transcription factor TIEG.
Gene ID
7071|8462
Swiss Prot
O14901|Q13118
Accession Number
NP_001171187.1
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human KLF10/11.
Target
Transcription factor (PubMed:9748269, PubMed:10207080) . Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492) . Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity) . Induces apoptosis (By similarity) .|Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity) . May play a role in the cell cycle regulation.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
52 kDa
Notes
Formerly GWB-ASD632
Specificity
KLF10/11 antibody detects endogenous levels of total KLF10/11 protein.
NCBI Gene Symbol
KLF10|KLF11
Host or Source
Rabbit
Protein Name
Krueppel-like factor 10|Krueppel-like factor 11
Gene Name URL
KLF10|KLF11

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