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SOX18 Antibody

CAT: 0247-OAAF02331-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF02331-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
SRY-box transcription factor 17|SRY-box transcription factor 18|SRY-box transcription factor 8|SRY-box transcription factor 9
Gene Aliases
CMD1; CMPD1; HLTRS; HLTS; SRA1; SRXX2; SRXY10; SRY (sex determining region Y) -box 17; SRY (sex determining region Y) -box 18; SRY (sex determining region Y) -box 8; SRY (sex determining region Y) -box9; SRY (sex-determining region Y) -box 9 protein; SRY-box 17; SRY-box 18; SRY-box 8; SRY-box 9; SRY-related HMG-box transcription factor SOX17; SRY-related HMG-box, gene 9; transcription factor SOX-17; transcription factor SOX-18; transcription factor SOX-8; transcription factor SOX-9; VUR3.
Gene ID
30812|54345|64321|6662
Swiss Prot
P35713|P48436|P57073|Q9H6I2
Accession Number
NP_060889.1
Reactivity
Human|Monkey|Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human SOX8/9/17/18.
Target
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity) .|Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site.|May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity) .|Transcriptional regulator (PubMed:24038782) . Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity) . Plays a role in chondrocyte differentiation (By similarity) . Important for normal skeletal development (PubMed:24038782) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
47 kDa
Notes
Formerly GWB-ASD573
Specificity
SOX8/9/17/18 antibody detects endogenous levels of total SOX8/9/17/18 protein.
NCBI Gene Symbol
SOX17|SOX18|SOX8|SOX9
Host or Source
Rabbit
Protein Name
Transcription factor SOX-17|Transcription factor SOX-18|Transcription factor SOX-8|Transcription factor SOX-9
Gene Name URL
SOX17|SOX18|SOX8|SOX9

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