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PRKAG1 Antibody

CAT: 0247-OAAF02319-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF02319-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Protein kinase AMP-activated non-catalytic subunit gamma 1|protein kinase AMP-activated non-catalytic subunit gamma 2|protein kinase AMP-activated non-catalytic subunit gamma 3
Gene Aliases
5'-AMP-activated protein kinase subunit gamma-1;5'-AMP-activated protein kinase subunit gamma-2;5'-AMP-activated protein kinase subunit gamma-3;5'-AMP-activated protein kinase, gamma-1 subunit;5'-AMP-activated protein kinase, gamma-3 subunit; AAKG; AAKG2; AMPK gamma1; AMPK gamma-1 chain; AMPK gamma3; AMPK gamma-3 chain; AMPK subunit gamma-2; AMPK subunit gamma-3; AMPKG; AMPKG3; CMH6; epididymis secretory sperm binding protein; H91620p; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catalytic subunit; SMGMQTL; WPWS.
Gene ID
51422|53632|5571
Swiss Prot
P54619|Q9UGI9|Q9UGJ0
Accession Number
NP_001193638.1
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PRKAG1/2/3.
Target
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
37 kDa
Notes
Formerly GWB-ASD562
Specificity
PRKAG1/2/3 antibody detects endogenous levels of total PRKAG1/2/3 protein.
NCBI Gene Symbol
PRKAG1|PRKAG2|PRKAG3
Host or Source
Rabbit
Protein Name
5'-AMP-activated protein kinase subunit gamma-1|5'-AMP-activated protein kinase subunit gamma-2|5'-AMP-activated protein kinase subunit gamma-3
Gene Name URL
PRKAG1|PRKAG2|PRKAG3

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