Products for Research Use Only
RegisterLogin

DKC1 Antibody

CAT: 0247-OAAF02046-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OAAF02046-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Name
Dyskerin pseudouridine synthase 1
Gene Aliases
CBF5; CBF5 homolog; DKC; DKCX; dyskeratosis congenita 1, dyskerin; Dyskerin; H/ACA ribonucleoprotein complex subunit 4; H/ACA ribonucleoprotein complex subunit DKC1; NAP57; NOLA4; nopp140-associated protein of 57 kDa; nucleolar protein family A member 4; nucleolar protein NAP57; snoRNP protein DKC1; XAP101.
Gene ID
1736
Swiss Prot
O60832
Accession Number
NP_001354.1
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Dyskerin.
Target
Isoform 1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674) . This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674) . Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674) . Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
57 kDa
Notes
Formerly GWB-ASD319
Specificity
Dyskerin antibody detects endogenous levels of total Dyskerin protein.
NCBI Gene Symbol
DKC1
Host or Source
Rabbit
Protein Name
H/ACA ribonucleoprotein complex subunit DKC1
Gene Name URL
DKC1

Related Products

CatalogName
OPCD00580-10UGDKC1 Recombinant Protein
OPCD00581-10UGDKC1 Recombinant Protein
OPCD00581-50UGDKC1 Recombinant Protein
OPCD00582-10UGDKC1 Recombinant Protein
OCOA19102-20UGDKC1 Protein Lysate
OPCD00580-200UGDKC1 Recombinant Protein
OPCD00580-50UGDKC1 Recombinant Protein
OPCD00582-50UGDKC1 Recombinant Protein
OPCD00582-200UGDKC1 Recombinant Protein
OCOA00477-20UGDKC1 Protein Lysate

Alternative Products

CatalogName
MBS9607322-01DKC1 Antibody

Popular Products