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IL6ST Antibody

CAT: 0247-OAAF00983-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF00983-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Interleukin 6 cytokine family signal transducer
Gene Aliases
CD130; CD130 antigen; CDW130; GP130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; HIES4; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB; interleukin receptor beta chain; interleukin-6 receptor subunit beta; interleukin-6 signal transducer; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha; sGP130.
Gene ID
3572
Swiss Prot
P40189
Accession Number
NP_001177910.1
Reactivity
Human|Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human CD130/gp130.
Target
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637) . That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003) . Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity) . Has a role in embryonic development (By similarity) . Does not bind IL6 (PubMed:2261637) . Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity) . Required for expression of TRPA1 in nociceptive neurons (By similarity) . Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity) . Required for normal trabecular bone mass and cortical bone composition (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
103 kDa
Notes
Formerly GWB-ASC391
Specificity
CD130/gp130 (Ab-782) antibody detects endogenous levels of total CD130/gp130 protein
NCBI Gene Symbol
IL6ST
Host or Source
Rabbit
Protein Name
Interleukin-6 receptor subunit beta
Gene Name URL
IL6ST

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