KCNQ3 Antibody (Phospho-Thr246)

9007-83-4

Potassium voltage-gated channel subfamily Q member 2|potassium voltage-gated channel subfamily Q member 3|potassium voltage-gated channel subfamily Q member 4|potassium voltage-gated channel subfamily Q member 5

BFNC; BFNC2; DEE7; DFNA2; DFNA2A; EBN; EBN1; EBN2; ENB1; HNSPC; KCNA11; KQT-like 2; KQT-like 3; KQT-like 4; KQT-like 5; KV7.2; KV7.3; KV7.4; Kv7.5; MRD46; neuroblastoma-specific potassium channel subunit alpha KvLQT2; potassium channel KQT-like 4; potassium channel protein; potassium channel subunit alpha KvLQT3; potassium channel subunit alpha KvLQT4; potassium channel subunit alpha KvLQT5; potassium channel, voltage gated KQT-like subfamily Q, member 2; potassium channel, voltage gated KQT-like subfamily Q, member 3; potassium channel, voltage gated KQT-like subfamily Q, member 4; potassium channel, voltage gated KQT-like subfamily Q, member 5; potassium channel, voltage-gated, subfamily Q, member 3; potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, KQT-like subfamily, member 4; voltage-gated potassium channel subunit Kv7.2; voltage-gated potassium channel subunit Kv7.3; Voltage-gated potassium channel subunit Kv7.4; voltage-gated potassium channel subunit Kv7.5.

3785|3786|56479|9132

O43525|O43526|P56696|Q9NR82

NP_001191753.1

Human|Mouse|Rat

The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246.

Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.|Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.|Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363) . As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873) .|Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.

Polyclonal Antibody

Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

The optimal working dilution should be determined by the end user.

Liquid

-20°C

96 kDa

Formerly GWB-ASB515

Kv7.3/KCNQ3 (Phospho-Thr246) antibody detects endogenous levels of Kv7.3/KCNQ3 only when phosphorylated at threonine 246.

KCNQ2|KCNQ3|KCNQ4|KCNQ5

Rabbit

Potassium voltage-gated channel subfamily KQT member 2|Potassium voltage-gated channel subfamily KQT member 3|Potassium voltage-gated channel subfamily KQT member 4|Potassium voltage-gated channel subfamily KQT member 5