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MAPK10 Antibody

CAT: 0247-OAAD00436-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OAAD00436-100UGSize:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Aliases
Jnk3, SAPb, SAPKC, Serk2
Gene ID
25272
Swiss Prot
B0VXR6
Reactivity
Human
Target
MAPK10 (mitogen-activated protein kinase 10), also called JNK3, which is located on chromosome 4q22.1- q23, JNK is an important contributor to stress-induced apoptosis, its isoforms (JNK1, JNK2, and JNK3) have distinct roles in cerebral ischemia. JNK1 is the major isoformresponsible for the high level of basal JNK activity in the brain. In contrast, targeted deletion of Jnk3 not only reduces the stress-induced JNK activity, but also protects mice from brain injury after cerebral ischemia- hypoxia. The downstream mechanism of JNK3-mediated apoptosis include the induction of Bim and Fas and the mitochondrial release of cytochrome c. which sug- gest that JNK3 is a potential target for neuroprotection therapies in stroke. JNK3 is crucial for neuronal apoptosis (stress-induced) and selectively expressed in the nervous system and heart.
Clonality
Monoclonal
Clone
2G12H3
Type
Monoclonal Antibody
Applications
WB
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Fragment
IgG1
NCBI Gene Symbol
MAPK10
Host or Source
Mouse
Protein Name
JNK3 protein
Gene Name URL
Mapk10

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