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LAL Antibody

CAT: 0247-OAAD00420-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OAAD00420-100UGSize:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Aliases
LAL, CESD
Gene ID
3988
Swiss Prot
P38571
Reactivity
Human
Immunogen
Ni-NTA purified truncated recombinant LAL expressed in E.coli strain BL21 (DE3)
Target
Lysosomal acid lipase (LAL), with 378-amino acid protein (43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and tri-glycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intraly- sosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD) . As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.
Clonality
Monoclonal
Clone
9G7F12
Type
Monoclonal Antibody
Applications
WB
Purification
Purified by protein A affinity chromatography.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid//
Reconstitution
Store at -20C.
Molecular Weight
43-54 kDa
Fragment
IgG1
NCBI Gene Symbol
LIPA
Protein Name
Lysosomal acid lipase/cholesteryl ester hydrolase
Gene Name URL
LIPA

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