Products for Research Use Only
RegisterLogin

RPTOR Antibody

CAT: 0247-OAAB18665-400ULSize: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OAAB18665-400ULSize:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Aliases
KOG1, Mip1
Gene ID
57521
Swiss Prot
Q8N122
Reactivity
Human, Mouse, Rat
Immunogen
This RPTOR antibody is generated from a mouse immunized with recombinant protein.
Target
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E) . mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
Clonality
Monoclonal
Clone
1411CT316.2.151.34
Type
Monoclonal Antibody
Applications
IHC-P, WB
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid.// PBS with 0.09% (W/V) sodium azide.
Reconstitution
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
149 kDa
Fragment
IgG1, k
NCBI Gene Symbol
RPTOR
Host or Source
Mouse
Gene Name URL
RPTOR

Related Products

CatalogName
OACA12604-100ULRPTOR Recombinant Antibody [1B10] (OACA12604)
OKEH01117-96WRPTOR ELISA Kit (Human)
OKEH05416-96WRPTOR ELISA Kit (Mouse)
OKEH05416RPTOR ELISA Kit (Mouse) (OKEH05416)
OKEH01117RPTOR ELISA Kit (Human) : 96 Wells (OKEH01117)
OACD01074-100ULWAS Antibody
OAMA00822-1MGWAS Antibody
OAMA00821-1MGWAS Antibody
OASG07565-100ULWAS Antibody
OACD00878-100ULAT Antibody

Alternative Products

CatalogName
MBS7050835-01RPTOR Antibody

Popular Products