Kahweol

• Description :

  Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

• UNSPSC :

  12352005

• Target :

  AMPK; Apoptosis

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Epigenetics; PI3K/Akt/mTOR

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/kahweol.html

• Purity :

  99.9

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C5=C(OC=C5)C=C2)C[C@@]([C@](CO)(O)C4)([H])CC3

• Molecular Formula :

  C20H26O3

• Molecular Weight :

  314.42

• References & Citations :

  [1]Seo HY, et al. Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway. Oncotarget. 2017 Aug 1;8 (50) :87086-87094.|[2]Baek JH, et al. Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK) . BMB Rep. 2017 Nov;50 (11) :566-571.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [6894-43-5]