Kahweol

• Description:

  Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

• UNSPSC:

  12352005

• Target:

  AMPK; Apoptosis

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Epigenetics; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kahweol.html

• Purity:

  99.9

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C[C@]12[C@@]3 ([H]) [C@@]4 (CC[C@]1 ([H]) C5=C (OC=C5) C=C2) C[C@@] ([C@] (CO) (O) C4) ([H]) CC3

• Molecular Formula:

  C20H26O3

• Molecular Weight:

  314.42

• References & Citations:

  [1]Seo HY, et al. Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway. Oncotarget. 2017 Aug 1;8 (50) :87086-87094.|[2]Baek JH, et al. Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK) . BMB Rep. 2017 Nov;50 (11) :566-571.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  6894-43-5