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7-Methylcoumarin

CAT: 0804-HY-N5092-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-N5092-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem[1][2][3].
CAS Number
2445-83-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/7-methylcoumarin.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC=C(C)C=C2O1
Molecular Formula
C10H8O2
Molecular Weight
160.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Sancheti S, et, al. Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats. Drug Chem Toxicol. 2013 Jan;36 (1) :42-7.|[2]Juvonen, R. O., et al., (2016) . Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes. Xenobiotica; the fate of foreign compounds in biological systems, 46 (1), 14–24.|[3]Keightley, A. M., et al., (1996) . Coumarin and its 4- and 7- Substituted Derivatives as Retardants of Mitoses in Allium Root Promeristem. International Journal of Pharmacognosy, 34 (2), 105–113.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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