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Binucleine 2

CAT: 0804-HY-121998Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121998Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki=0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 μM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.
CAS Number
220088-42-6
UNSPSC
12352005
Hazard Statement
H301-H318
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/binucleine-2.html
Smiles
CN(/C=N/C1=C(C=NN1C2=CC=C(C(Cl)=C2)F)C#N)C
Molecular Formula
C13H11ClFN5
Molecular Weight
291.71
Precautions
P264-P270-P280-P305+P351+P338-P330-P405-P501
References & Citations
[1]Smurnyy, et al. Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. ACS Chem Biol. 5 (11), 1015-1020 (2010) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora B

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