Nebivolol (hydrochloride)

Nebivolol (hydrochloride)

• CAS Number: 152520-56-4
• UNSPSC Description: Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2].
• Target Antigen: Adrenergic Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease; Endocrinology; Cancer
• Assay Protocol: https://www.medchemexpress.com/nebivolol-hydrochloride.html
• Purity: 99.89
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 1.79 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: FC1=CC=C2C(CC[C@]([C@@H](O)CNC[C@H](O)[C@@]3([H])CCC(C=C(F)C=C4)=C4O3)([H])O2)=C1.Cl
• Molecular Weight: 441.90
• References & Citations: [1]Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49(2):430-9.|[2]Thomas Münzel, et al. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009 Oct 13;54(16):1491-9. Nat Commun. 2024 Sep 16;15(1):8130.|Virology. 2023 Jun 21.|J Pharmaceut Biomed. 2020, 113870.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched