HLA-C Antibody - C-terminal region

• Gene Name:

  Major histocompatibility complex, class I, C

• Gene Aliases:

  MHC, HLAC, HLC-C, D6S204, PSORS1, HLA-JY3

• Gene ID:

  3107

• Swiss Prot:

  Q29960

• Accession Number:

  NP_002108

• Reactivity:

  Human, Pig, Rabbit

• Target:

  HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin) . The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.

• Partner Proteins:

  UBC; RNF139; NEDD8; SUMO1; ADRB2; MMS19; YBX1; CDC25A; BATF2; PRRG4; env; TANK; FBXO6; PCK1; CXCR4; KIR2DL2; KIR2DL1; LILRB2; KIR2DL3; TAPBP; LILRB1; KIR2DS4; KIR2DS2; KIR2DS1; CD8A; TAP2; HSPA5; B2M; CALR; HLA-C

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  PPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVET

• Applications:

  WB

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Homology:

  Human: 100%; Pig: 100%; Rabbit: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  38kDa

• Protein Length:

  366

• NCBI Gene Symbol:

  HLA-C

• Host or Source:

  Rabbit

• Protein Name:

  HLA class I histocompatibility antigen, Cw-16 alpha chain

• Gene Name URL:

  HLA-C

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_002117