PTPN6 antibody - middle region (ARP61398_P050)

• Gene Name:

  Protein tyrosine phosphatase, non-receptor type 6

• Gene Aliases:

  HCP, HCPH, SHP1, SHP-1, HPTP1C, PTP-1C, SHP-1L, SH-PTP1

• Gene ID:

  5777

• Swiss Prot:

  P29350

• Accession Number:

  NP_002822

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Target:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.

• Partner Proteins:

  FHL3; UBC; Siglece; PANK4; SAMD4B; SMAD3; TXN; CD300LF; SIGLEC12; LILRB4; LILRB2; TREML1; KIR2DL3; SPATA2; C6orf25; KLRAP1; TMEM62; PILRB; SIGLEC10; FCGR2B; CUZD1; BTLA; SIGLEC11; SLAMF6; TLR10; GAB2; PAG1; PILRA; CLEC4A; KIR2DL5A; ACTN4; BLNK; STAT5B; IR

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  WEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDS

• Applications:

  WB

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  65kDa

• Protein Length:

  595

• NCBI Gene Symbol:

  PTPN6

• Host or Source:

  Rabbit

• Protein Name:

  Tyrosine-protein phosphatase non-receptor type 6

• Gene Name URL:

  PTPN6

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_002831