TOB1 Antibody - middle region

• Gene Name:

  Transducer of ERBB2, 1

• Gene Aliases:

  TOB, TROB, APRO5, APRO6, PIG49, TROB1

• Gene ID:

  10140

• Swiss Prot:

  P50616

• Accession Number:

  NP_005740

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Horse, Pig, Yeast

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human TOB1

• Target:

  This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.

• Partner Proteins:

  CORO7; APP; DTL; CDC7; PABPC1; CHAF1A; PAN2; UBR5; ELAVL1; SMAD3; CTNNB1; UBC; SKP2; SCMH1; MARCKS; SETDB1; CNOT7; SMAD9; SMAD5; SMAD6; SMAD1; SMAD2; SMAD4; MAPK1; ERBB2; RPS6KA1; MAPK9

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  DLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKT

• Applications:

  WB

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 82%; Pig: 93%; Rat: 92%; Yeast: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  38kDa

• Protein Length:

  345

• NCBI Gene Symbol:

  TOB1

• Host or Source:

  Rabbit

• Protein Name:

  Protein Tob1

• Gene Name URL:

  TOB1

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_005749