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Benastatin B

CAT: 0804-HY-N12261Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N12261Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Benastatin B is an inhibitor for glutathione S-transferase, that inhibits human pi class GST with an IC50 of 1.10 μg/mL. Benastatin B exhibits board-spectrum antibacterial efficacy, inhibits MRSA with MIC 3.1 μg/mL. Benastatin B exhibits anti-inflammatory efficacy through inhibition of IgE mediated β-hexosaminidase release with an IC50 of 79 μg/mL[1][2].
CAS Number
138968-86-2
UNSPSC
12352005
Target
Bacterial; Glutathione S-transferase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/benastatin-b.html
Smiles
O=C(C1=C(C2=C(C=C1CCCCC)CCC3=C2C=C4C(C(C5=C(C4(C)C)C=C(O)C=C5O)=O)=C3O)O)O
Molecular Formula
C30H30O7
Molecular Weight
502.56
References & Citations
[1]Aoyama T, et al., Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. II. Structure determination of benastatins A and B. J Antibiot (Tokyo) . 1992 Sep;45 (9) :1391-6. |[2]Tsakem B, et al., Structures, biosynthesis and biological activities of benastatins, anthrabenzoxocinones and fredericamycins. Bioorg Chem. 2024 Sep;150:107572.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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