SOS1 agonist-1
CAT:
804-HY-153606-02
Size:
10 mM / 1 mL
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SOS1 agonist-1
- CAS Number: 2245237-61-8
- UNSPSC Description: SOS1 agonist-1 (compound 79) is an agonist for the Son of sevenless homologue SOS1. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP to GTP on RAS and regulates RAS activation. SOS1 agonists increase nucleotide exchange on RAS, enhance cellular RAS-GTP levels, and trigger biphasic signaling changes in ERK1/2 phosphorylation. Play an anti-cancer role[1].
- Target Antigen: Ras
- Type: Reference compound
- Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
- Applications: Cancer-programmed cell death
- Field of Research: cancer
- Assay Protocol: https://www.medchemexpress.com/sos1-agonist-1.html
- Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(N1CC2(CN(C2)C3=NC4=C(N3CC5=CC(C)=C(F)C(C)=C5)C=C(Cl)C=C4Br)C1)OC(C)(C)C
- Molecular Weight: 563.89
- References & Citations: [1]Hodges TR, Abbott JR, Little AJ, Sarkar D, Salovich JM, Howes JE, Akan DT, Sai J, Arnold AL, Browning C, Burns MC, Sobolik T, Sun Q, Beesetty Y, Coker JA, Scharn D, Stadtmueller H, Rossanese OW, Phan J, Waterson AG, McConnell DB, Fesik SW. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61(19):8875-8894.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported