PPARG Antibody - N-terminal region

• Gene Name:

  Peroxisome proliferator-activated receptor gamma

• Gene Aliases:

  GLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARG5, PPARgamma

• Gene ID:

  5468

• Swiss Prot:

  P37231

• Accession Number:

  NP_056953

• Reactivity:

  Human, Dog, Pig

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human PPARG

• Target:

  PPARG is a receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPARG is the key regulator of adipocyte differentiation and glucose homeostasis.This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

• Partner Proteins:

  HDAC3; NCOA1; NCOA3; SUMO1; UBC; SUMO2; RXRA; MED1; HMGA1; EP300; NCOA2; CDC34; PRKAA2; PRKAA1; PPARGC1A; ASH2L; RBBP5; NSD1; NCOA6; PAXIP1; MUC1; NR3C1; SMAD2; CREBBP; ALOX15B; ZFYVE9; USP7; NCOR1; CDK5; SMARCD3; SMARCA4; NEDD4; BCAS2; MIF4GD; MED14; JAZ

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL

• Applications:

  WB

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Homology:

  Dog: 92%; Human: 100%; Pig: 85%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  57kDa

• Protein Length:

  505

• NCBI Gene Symbol:

  PPARG

• Host or Source:

  Rabbit

• Protein Name:

  Peroxisome proliferator-activated receptor gamma

• Gene Name URL:

  PPARG

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_015869