E2F6 Antibody - middle region

• Gene Name :

  E2F transcription factor 6

• Gene Aliases :

  E2F-6

• Gene ID :

  1876

• Swiss Prot :

  Q6Q9Z5

• Accession Number :

  NP_997705

• Reactivity :

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig

• Immunogen :

  The immunogen is a synthetic peptide directed towards the middle region of human E2F6

• Target :

  E2F6 is a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants encoding several different isoforms have been found for this gene.

• Partner Proteins :

  TFDP2; TFDP1; KRTAP10-7; LYN; ARAF; APP; PCGF6; RYBP; YAF2; RNF2; SMARCAD1; UBC; L3MBTL2; EZH2; Epc1; EED; KMT2D; KMT2A; RING1; E2F1; BMI1; ZMYND8; ZMYND11; KDM5C; EZH1; CBX3; E2F6

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Sequence :

  HEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTS

• Applications :

  IHC, WB

• Purification :

  Protein A purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1.0 mg/ml

• Homology :

  Cow: 92%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%

• Format :

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution :

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight :

  14kDa

• Protein Length :

  129

• NCBI Gene Symbol :

  E2F6

• Host or Source :

  Rabbit

• Protein Name :

  E2F6 splice variant f EMBL AAT02641.1

• Gene Name URL :

  E2F6

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_212540