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Talampanel

CAT: 0804-HY-15079-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15079-01Size:5 mg
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Description
Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity[1]. Talampanel (IVAX) has neuroprotective effects in rodent stroke models[2]. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain[2].
CAS Number
161832-65-1
Product Name Alternative
GYKI-53773; LY-300164
UNSPSC
12352005
Hazard Statement
H301, H401
Target
Apoptosis; iGluR
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Talampanel.html
Concentration
10mM
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]1CC2=C(C=C(OCO3)C3=C2)C(C4=CC=C(N)C=C4)=NN1C(C)=O
Molecular Formula
C19H19N3O3
Molecular Weight
337.37
Precautions
H301, H401
References & Citations
[1]Paizs M, et al. Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically. Amyotroph Lateral Scler. 2011 Sep;12 (5) :340-4.|[2]Denes L, et al. Talampanel a non-competitive AMPA-antagonist attenuates caspase-3 dependent apoptosis in mouse brain after transient focal cerebral ischemia. Brain Res Bull. 2006 Jul 31;70 (3) :260-2. Epub 2006 Mar 31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
AMPA Receptor

Alternative Products

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BA2994-5Talampanel
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A15515-100Talampanel 100mg
A15515-50Talampanel 50mg
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A15515-2Talampanel 2mg
A15515-10Talampanel 10mg
SF8997-10mMTalampanel (AMPAR antagonist)
MBS130941-01Talampanel?LY-300164?
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