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Cilostazol (Standard)

CAT: 0804-HY-17464R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17464R-01Size:5 mg
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Description
Cilostazol (Standard) is the analytical standard of Cilostazol. This product is intended for research and analytical applications. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM[1][2].
CAS Number
73963-72-1
Product Name Alternative
OPC 13013 (Standard)
UNSPSC
12352005
Target
Autophagy; Phosphodiesterase (PDE) ; Reference Standards
Type
Reference Standards
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/cilostazol-standard.html
Smiles
O=C1NC2=C(C=C(OCCCCC3=NN=NN3C4CCCCC4)C=C2)CC1
Molecular Formula
C20H27N5O2
Molecular Weight
369.46
References & Citations
[1]Schr?r K. The pharmacology of cilostazol. Diabetes Obes Metab. 2002 Mar;4 Suppl 2:S14-9.|[2]Minami N, et al. Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo. Life Sci. 1997;61 (25) :PL 383-9.|[3]Saito S, et al. Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis. Hepatol Res. 2013 Apr 19.|[4]Ye YL, et al. Cilostazol, a phosphodiesterase 3 inhibitor, protects mice against acute and late ischemic brain injuries.Eur J Pharmacol. 2007 Feb 14;557 (1) :23-31. Epub 2006 Nov 10.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Cilostazol

Cilostazol is a lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group. It has a role as a bronchodilator agent, a vasodilator agent, a fibrin modulating drug, an anticoagulant, a platelet aggregation inhibitor, an EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor and a neuroprotective agent. It is a lactam and a member of tetrazoles.

CAS Number73963-72-1
PubChem CID2754
IUPAC Name6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one
Molecular FormulaC20H27N5O2
Molecular Weight369.5
XLogP3.1
Topological Polar Surface Area81.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity485
SMILES
C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
InChI
InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
InChIKey
RRGUKTPIGVIEKM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cilostazol
CAS: 73963-72-1
CID: 2754
Formula: C20H27N5O2
MW: 369.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight369.5
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass369.21647512
Monoisotopic Mass369.21647512
Topological Polar Surface Area81.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity485
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
A4337-5.1Cilostazol

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