Dichlorophenyl-ABA

• Description :

  Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Transthyretin (TTR)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/dichlorophenyl-aba.html

• Purity :

  99.79

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1=CC=CC=C1NC2=CC(Cl)=CC(Cl)=C2

• Molecular Formula :

  C13H9Cl2NO2

• Molecular Weight :

  282.12

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Cardoso I, et al. Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design. Biochem J. 2007 Nov 15;408 (1) :131-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [18201-65-5]