OTS186935

• Description :

  OTS186935 is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 regulates the production of γ-H2AX in cancer cells[1].

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ots186935.html

• Purity :

  99.69

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=C(Cl)C=C(C2=CN3C=CC(N4C[C@@H](NCC5=CC=NC=C5)CC4)=CC3=N2)C(OC)=C1

• Molecular Formula :

  C25H26ClN5O2

• Molecular Weight :

  463.96

• References & Citations :

  [1]Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9 (61) :31820-31831.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  SUV39H2/KMT1B

• Citation 01 :

  Acta Neuropathol. 2022 Nov;144 (5) :1027-1048.|Cell Death Discov. 2025 Aug 23;11 (1) :402.|Research Square Preprint. 2024 Feb 7.|Mol Cell. 2024 Nov 25:S1097-2765 (24) 00914-6.

• CAS Number :

  [2093400-18-9]