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Ilorasertib

CAT: 0931-TQ0059-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TQ0059-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1227939-82-3
Target
Aurora Kinase, c-RET, VEGFR, FLT, PDGFR
Related Pathways
Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Angiogenesis, Cell Cycle/Checkpoint, Apoptosis
Purity
0.9803
Bioactivity
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM) . It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM) .
Smiles
NC1=C2C(=C(C=N1)C3=CN(CCO)N=C3)SC=C2C4=CC=C(NC(NC5=CC(F)=CC=C5)=O)C=C4
Molecular Formula
C25H21FN6O2S
Molecular Weight
488.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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