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Cannflavin B

CAT: 0804-HY-W749694-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W749694-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cannflavin B is a flavonoid compound that can be isolated from Cannabis sativa L. Cannflavin B is inhibitors of PGE2 release (IC50: 0.7 μM), mPGES-1 (IC50: 3.7 μM), and 5-lipoxygenase. Cannflavin B has multiple activities such as anti-inflammatory, antioxidant, anti-glycation, anti-ferroptosis, anti-tumor, and anti-Leishmania (IC50: 14 μM) . Cannflavin B can also inhibit the TrkB-BDNF signaling pathway[1][2][3][4].
CAS Number
76735-58-5
Product Name Alternative
Canniflavone
UNSPSC
12352005
Target
Akt; Ferroptosis; Lipoxygenase; mTOR; p38 MAPK; Parasite; PGE synthase; Trk Receptor
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cannflavin-b.html
Purity
98.36
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC(OC)=C(O)C=C2)OC3=CC(O)=C(C/C=C(C)\C)C(O)=C13
Molecular Formula
C21H20O6
Molecular Weight
368.38
References & Citations
Cannabis sativa[1]
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-LOX; TrkB

Chemical Information

Cannflavin B

cannflavin B has been reported in Cannabis sativa and Dorstenia mannii with data available.

CAS Number76735-58-5
PubChem CID403815
IUPAC Name5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-(3-methylbut-2-enyl)chromen-4-one
Molecular FormulaC21H20O6
Molecular Weight368.4
XLogP4.6
Topological Polar Surface Area96.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity608
SMILES
CC(=CCC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC(=C(C=C3)O)OC)O)C
InChI
InChI=1S/C21H20O6/c1-11(2)4-6-13-15(23)9-19-20(21(13)25)16(24)10-17(27-19)12-5-7-14(22)18(8-12)26-3/h4-5,7-10,22-23,25H,6H2,1-3H3
InChIKey
IXCUTZUASDSIJO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cannflavin B
CAS: 76735-58-5
CID: 403815
Formula: C21H20O6
MW: 368.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.4
XLogP34.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass368.12598835
Monoisotopic Mass368.12598835
Topological Polar Surface Area96.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity608
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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