Balixafortide

CAT: 0931-MF-0051668-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0051668-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1051366-32-5
Target
CXCR|||Arrestin
Related Pathways
Immunology/Inflammation|||GPCR/G Protein|||Autophagy
Bioactivity
Balixafortide (POL6326) is a potent, selective, and well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM, and also acts as a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. It demonstrates anti-cancer effects[1][2], blocks ?-arrestin recruitment and calcium flux with IC50s < 10 nM, and is 1000-fold more selective for CXCR4 than a large panel of receptors, including CXCR7.
Smiles
[H][C@]12CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCN)NC2=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@]2([H])C(=O)N2CCC[C@@]2([H])C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](C)C(=O)N1
Molecular Formula
C84H118N24O21S2
Molecular Weight
1864.14
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Alternative Products

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HY-P1682-01Balixafortide
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A24310-10Balixafortide (POL6326) 10mg
A24310-100Balixafortide (POL6326) 100mg
A24310-5Balixafortide (POL6326) 5mg
205864Balixafortide TFA salt
A24310-50Balixafortide (POL6326) 50mg

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