CH 275

• Target:

  Somatostatin

• Related Pathways:

  GPCR/G Protein

• Bioactivity:

  Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 ?M, > 10 ?M and > 10?M for human sst1, sst3, sst4, sst2 and sst5 respectively) . Attenuates somatostatin release in the rat nucleus accumbens.

• Smiles:

  C(C=1C=2C(NC1)=CC=CC2)[C@@H]3C(=O)N[C@@H](CC4=CC=C(CNC(C)C)C=C4)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CSSC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=CC=C7)C(=O)N3)[H])[H]

• Molecular Formula:

  C74H96N14O15S2

• Molecular Weight:

  1485.8

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  174688-78-9