Obtustatin

• Target:

  Integrin

• Related Pathways:

  Cytoskeletal Signaling

• Bioactivity:

  Highly potent integrin ?1?1 inhibitor (IC50 = 0.8 nM for ?1?1 binding to type IV collagen) . Selective for ?1?1 over ?2?1, ?IIb?3, ?v?3, ?4?1, ?5?6, ?9?1 and ?4?7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.

• Molecular Formula:

  C184H284N52O57S8

• Molecular Weight:

  4393.07

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C